http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111362972-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 |
| filingDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111362972-B |
| titleOfInvention | Benzimidazole [2,1-b ] thiazole compound and application thereof |
| abstract | The invention discloses a benzimidazole [2,1-b ]]Thiazole compounds and application thereof, belonging to the technical field of medicines. Benzimidazo [2,1-b ] synthesized in the present invention]The inhibition activity of the thiazole analogue on FLT3 reaches more than 90 percent, wherein, the IC of the compound (compounds 2, 4, 6, 8 and 10) on FLT3-ITD kinase 50 Lower values, especially for Compound 2, IC 50 The value is only 5.60nM, therefore, the compounds of the invention can be used as inhibitors of FLT3, or for the preparation of medicaments capable of modulating or inhibiting diseases associated with abnormal cell proliferation by affecting the enzymatic activity of one or more tyrosine kinases and interfering with the signals transduced by said kinases, with wide application prospects. |
| priorityDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 280.