http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111362874-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 |
| filingDate | 2020-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111362874-B |
| titleOfInvention | Preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid |
| abstract | The invention discloses a preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid, belonging to the technical field of organic synthesis. 2, 2-difluoro acetyl halide is used as a raw material, and is subjected to addition reaction with alpha, beta-unsaturated ester and alkaline hydrolysis to obtain alpha-difluoro acetyl intermediate carboxylic acid; then condensing and cyclizing the product with methyl hydrazine water solution in the presence of a catalyst to obtain a crude product of the 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid; recrystallizing to obtain the pure product of the 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid. The method has the advantages of simple operation, easily obtained raw materials, high reaction yield, reduction of isomers in the reaction process through various ways, and convenience in product purification. |
| priorityDate | 2020-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.