| abstract |
The invention discloses a flavonol derivative and a preparation method and application thereof. Specifically, the present invention discloses a flavonol derivative represented by formula I, or a pharmaceutically acceptable salt thereof, or an enantiomer, diastereomer, tautomer, or solvate thereof. , polymorph or prodrug, wherein, R 1 and R 2 are independently selected from: -OH, -OC(=O)R a ; R a is a substituted or unsubstituted C 2 -C 12 alkenyl; R 3 is selected from: hydrogen, C 1 -C 6 substituted or unsubstituted alkoxy; R 4 is selected from: hydrogen, cyclic monosaccharide sugar group; Unless otherwise specified, the "substituted" refers to one of the groups or Multiple hydrogen atoms are substituted with substituents selected from the group consisting of -OH, C 1 -C 4 alkyl. The flavonol compound of the present invention has excellent hypolipidemic effect, and can significantly reduce the levels of TG, CHO and LDL-C in blood lipids. |