| abstract |
The invention discloses phenylpyrrolidine derivatives and a preparation method thereof. The general formula of such compounds is shown in formula (A), The compounds have novel structure, better efficacy, high bioavailability and strong druggability PDE4 inhibitors, which can be used to effectively treat PDE4-related diseases and disorders, including but not limited to inflammatory diseases, allergic diseases, autoimmunity Sexual diseases, transplant rejection, arthritic diseases, skin inflammatory diseases, inflammatory bowel diseases and diseases related to smooth muscle contractility, etc. |