http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111333581-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-56 |
| filingDate | 2020-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111333581-B |
| titleOfInvention | Synthetic method of ozagrel sodium |
| abstract | The invention discloses a synthetic method of ozagrel sodium, belonging to the technical field of medicines. The synthesis method comprises the following steps: firstly, 4-bromobenzyl bromide is used as a starting material and reacts with imidazole under the alkaline condition to generate a 1- (4-bromobenzyl) -1H-imidazole intermediate 1; reacting the 1- (4-bromobenzyl) -1H-imidazole with acrylic ester under the catalysis of palladium acetate to generate an ozagrel ester intermediate 2; and thirdly, carrying out alkaline hydrolysis on the ozagrel ester to obtain the sodium ozagrel product. The synthesis method has the advantages of easily available raw materials, low price cost, few steps, little pollution and the like, and is suitable for industrial production. |
| priorityDate | 2020-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.