http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111317864-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-414 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-227 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate | 2020-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111317864-B |
| titleOfInvention | Axially-gradient protein-loaded silk fibroin nerve conduit and preparation and application thereof |
| abstract | The invention relates to the field of biomedical engineering, and discloses a fibroin nerve conduit for axially gradient loading of protein, and preparation and application thereof. The silk fibroin modified by the o-nitrobenzyl photosensitive molecules is obtained by grafting the o-nitrobenzyl photosensitive molecules on silk fibroin, then the silk fibroin is prepared into a silk fibroin nerve conduit with optical activity, finally the silk fibroin nerve conduit is soaked in a nerve growth factor solution, the front end, the middle part and the tail end of the silk fibroin nerve conduit are irradiated by blue light along the axial direction, and the silk fibroin nerve conduit with the axially gradient loaded protein is obtained after washing and freeze-drying. The invention reduces the light irradiation time in the front end, the middle part and the terminal area of the silk fibroin nerve conduit in a gradient way, and realizes the accurate controllable gradient loading protein of the silk fibroin nerve conduit. The biological activity of the silk fibroin nerve conduit is greatly improved, the proliferation and migration of nerve cells can be effectively promoted, the rapid growth of new nerve tissues can be induced, and a good nerve repair effect can be achieved clinically. |
| priorityDate | 2020-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.