| abstract |
The invention discloses a class of compounds containing a 9,10-dihydrophenanthrene skeleton and a preparation method and application thereof. The compound has the structure shown in formula 3A or formula 3B: The compound of formula 1 can be reacted with the compound of formula 2 and acetic acid in the presence of a rhodium catalyst and a metal salt additive to obtain the compound of formula 3A; and then the compound of formula 3A can be hydrolyzed to obtain the compound of formula 3B; the specific reaction formula is as follows shown: The research results show that the compound with the structure represented by the formula 3A or the formula 3B provided by the present invention has the effect of inhibiting the proliferation of tumor cells, and is expected to be used as an active ingredient in the preparation of anti-tumor drugs, especially as an active ingredient in the preparation of anti-tumor drugs. The drug for liver cancer or breast cancer has broad medicinal prospects. |