http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111297864-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111297864-B |
| titleOfInvention | Application of a compound in the preparation of antitumor drugs |
| abstract | The invention discloses the application of a compound in the preparation of antitumor drugs. The inventor's research found that ZINC65387069 has strong kinase inhibitory activity, relatively high water solubility, low polar surface area, and small molecular weight and molecular volume. The phosphorylation level of BRAF protein in colorectal cancer cells treated with ZINC65387069 was significantly inhibited. By detecting the effect of ZINC65387069 on colorectal cancer cell migration, apoptosis and cytoskeleton, ZINC65387069 can inhibit cell migration, destroy cytoskeleton and promote cell apoptosis. ZINC65387069 has the characteristics of simple structure and small molecular weight, which is expected to be used as a lead compound for further structural optimization, and then to develop more effective anti-tumor drugs. |
| priorityDate | 2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 259.