| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be2c55a9de09e08e3404c0a5a1ae4dc7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K2201-011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K2201-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2351-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K2003-2275 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K3-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0221
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0231
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F275-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F265-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F275-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F265-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-56 |
| filingDate |
2020-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fa81f2b839ec13fafa46dfd62b13bb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fc3900454906150ff6ef0df2ac9572e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_552fbe669538d93665faf94eb35c6e7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1a2d2afccac854dbf2f48e4b73800b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b8358c79ba2e3309fb3de8b2087f02c |
| publicationDate |
2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111286044-A |
| titleOfInvention |
Dual-temperature-sensitive magnetic hydrogel for cell preservation and preparation method and application thereof |
| abstract |
The invention belongs to the field of cell preservation, and in particular relates to a dual temperature-sensitive magnetic hydrogel for preserving cells, a preparation method and application thereof. The preparation method of the dual-temperature-sensitive magnetic hydrogel for preserving cells adopts the following steps: (1) embedding magnetic nanoparticles in the hydrogel material to obtain magnetic hydrogel microspheres; (2) mixing the dual-temperature-sensitive polymer The surface of the magnetic hydrogel microspheres obtained in the step (1) is modified by the polymer to obtain magnetic dual-temperature-sensitive hydrogel particles. The dual temperature-sensitive magnetic hydrogel of the present invention self-assembles into a gel at an ambient temperature below the refrigerator temperature (4° C.) and above room temperature (25° C.), thereby simulating the three-dimensional structure of the extracellular matrix for long-term and efficient cell preservation. , while recovering the cells by simple physical means at the temperature at which the cells are separated from the material. The method effectively solves the problems of poor temperature selectivity, toxicity of preservatives, low cell viability and difficulty in cell recovery in traditional cell preservation methods. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111995769-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021167049-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111995769-B |
| priorityDate |
2020-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |