| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d87beca8d976674bd30f2322da43a806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e4872ac53b0f29d11e2480c476acdb1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate |
2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eff8a1bd547a7861d6a103a67820e597
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1369de5e6ba0e92d74e16b3c4570fa56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd7b990dabb434fd6b33ebb24ff75e18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0887334a1bb88a3b5288d80102e3ef29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f5e3b480549789122fa2342ddfd4554 |
| publicationDate |
2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111285936-A |
| titleOfInvention |
Acid-sensitive nanopeptides targeting tumors and their applications |
| abstract |
The invention discloses an acid-sensitive nano peptide segment targeting tumors and its application. The acid-sensitive nano-peptide segment targeting tumors includes a low-pH nano-insert peptide, a coupling agent, and an Fc fragment in series; wherein, the low-pH nano-insertion peptide includes the amino acid sequence of SEQ ID NO. 1 or its variants. The acid-sensitive nanopeptide targeting tumors utilizes the characteristics of the tumor microenvironment pH<7 and slightly acidic environment to insert specific markers into tumor cells and other stromal cells in the microenvironment, which can attract and bind to CD16 molecules of NK cells. On the other hand, the marker specifically recruits and activates the ADCC function of NK cells to achieve the killing function of tumor cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113896803-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113896803-B |
| priorityDate |
2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |