http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111285867-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-06 |
| filingDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111285867-B |
| titleOfInvention | Preparation method of benzoquinolizine derivative |
| abstract | The invention relates to a preparation method of a benzo-quinolizine derivative, belongs to the technical field of medicinal chemistry, and particularly relates to a chiral resolution method of tetrabenazine. The (3R,11bR) -tetrabenazine or (3S,11bS) -tetrabenazine with high optical purity is simply, conveniently and effectively prepared by taking tetrabenazine racemate as a raw material and performing the steps of salification with chiral acid, pulping, dissociation and the like. Compared with the prior art, the method has the advantages of mild reaction conditions in each step, high yield, simple and convenient operation and stable process, and is suitable for large-scale industrial production. |
| priorityDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.