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publicationDate 2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111278561-A
titleOfInvention Methods and systems for overall patterning of molecular structures
abstract Disclosed are methods, systems, and apparatus for overall patterning of nucleic acid molecular structures. The device may include microchannels and nanoslits. The microchannel and nanoslit can be connected by a docking chamber. The systems and methods can utilize the geometry of the device coordinated with the voltage application scheme to dock nucleic acid molecules within the docking chamber and then inject the nucleic acid molecules into the nanoslit. The method can be used to present nucleic acid molecules in a manner suitable for genomic analysis. The method can also be used to provide size selection of nucleic acid molecules.
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