| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d890ad239375a780e6827d3407f15ef3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2020-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_010f4688c10f53c806380b6085c75abf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89728eae7560174facb81290c075e364
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e07fc2b133e74800d8d7ce265e3e3459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a63b0719ac4ce4359a01f9dd7fc0a0f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75c2b864db3dc3294cf25df7e3d44b32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c580b7966328d7225ced1e81f931b97 |
| publicationDate |
2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111269242-A |
| titleOfInvention |
Norcantharidin carboxylate monofluorobenzyl ester and its synthetic method and antitumor application |
| abstract |
The invention provides a synthesis of norcantharidin carboxylate monofluorobenzyl ester represented by the structural formula I and its anti-tumor application. The specific structure of norcantharidin carboxylate monofluorobenzyl shown in formula I includes: The activity test shows that the norcantharidin carboxylate monofluorobenzyl ester as shown in I designed and synthesized by the present invention is a suitable anti-tumor drug candidate, especially as an anti-cancer drug candidate. Compared with the positive control drugs norcantharidin and norcantharidin sodium, the water solubility, stability and antitumor activity are improved. In addition, the synthesis method of norcantharidin carboxylate monofluorobenzyl ester of the present invention has easily available raw materials and is very easy to operate and implement. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115490701-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115490701-B |
| priorityDate |
2020-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |