| abstract |
The invention relates to a method for preparing chiral β-trifluoromethyl-β-hydroxy-α-amino acid and derivatives thereof, in particular: weighing tert-butyl glycine and derivatives thereof, trifluoromethyl ketone, acid and a chiral N-methylpyridoxal catalyst, adding a solvent, and reacting to generate the target product chiral β-trifluoromethyl-β-hydroxy-α-amino acid and its derivatives. Compared with the prior art, the present invention utilizes the pyridoxal catalyst without protecting and deprotecting the amino group, and realizes the simple and efficient synthesis of the chiral β-trifluoromethyl-β-hydroxy-α-amino acid derivative. |