http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111253263-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-50 |
| filingDate | 2020-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111253263-B |
| titleOfInvention | The preparation method of chloroquine key intermediate 2-amino-5-diethylaminopentane |
| abstract | The invention relates to the technical field of medicine and chemical industry, and discloses a preparation method of 2-amino-5-diethylaminopentane, a key intermediate of chloroquine. chemical reaction to obtain N,N-diethyllevulinic acid amide intermediate, and then hydrodeoxygenation and amination reaction of the intermediate and the mixed gas of hydrogen and ammonia occur under the action of a catalyst to obtain the 2 -Amino-5-diethylaminopentane, the method of the present invention has no chlorination process, thus avoiding the generation of chlorine-containing waste water, and has high environmental protection; the reaction steps are short and the overall yield is high, and ethyl levulinate is used as the raw material to calculate The molar yield of the first step is over 98%, the molar yield of the second step is over 92%, and the total molar yield is over 90%, which effectively improves the production capacity of 2-amino-5-diethylaminopentane. |
| priorityDate | 2020-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.