| abstract |
The invention relates to an electrospinning support with the functions of both treating melanoma and repairing damaged tissue and a preparation method thereof, belonging to the technical field of biomedical materials. The method uses iron-loaded bleomycin amorphous calcium carbonate composite nanoparticles with silicon layers modified on the surface, polycaprolactone, gelatin and hexafluoroisopropanol as raw materials, and prepares the scaffold by electrospinning. The ferrous ion bleomycin complex in the electrospinning scaffold can target melanoma cells, thereby promoting the accumulation of ferrous ions in melanoma cells, inducing the production of highly toxic free radicals, and at the same time promoting bleomycin It is mediated by DNA fragmentation to achieve the purpose of treating melanoma. In addition, after the electrospinning scaffold is degraded, the released Ca 2+ and gelatin can promote the migration of skin cells, the expression of vascular-related factors and the deposition of collagen, so as to achieve the purpose of repairing damaged tissue. The preparation method of the electrospinning stent in the present invention is simple, easy to operate, and suitable for enlarged production. |