http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111249340-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-66 |
| filingDate | 2018-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111249340-B |
| titleOfInvention | Systematic separation and purification method of rhizoma corydalis alkaloid |
| abstract | The invention provides a systematic separation and purification method of corydalis alkaloid. The preparation liquid chromatogram is adopted to efficiently separate and purify alkaloid monomers from alkaloid components, and the separation modes are reversed phase chromatogram and ion exchange chromatogram. The mobile phase consists of acetonitrile, methanol or ethanol with water (with the addition of a certain amount of acid or buffer salt). Linear gradient, step gradient or isocratic elution mode is adopted. Preparing the rhizoma corydalis micro-alkaloid component, the constant tertiary amine alkali component and the quaternary ammonium alkali component by two-dimensional reversed phase/reversed phase, reversed phase and ion exchange chromatography modes respectively. The method can realize the target preparation of alkaloid, can obtain batch of known active alkaloid, and simultaneously enrich and separate trace alkaloid, thereby continuously enriching alkaloid library and providing material basis for the activity research of alkaloid compounds and the development of new drugs with single component. |
| priorityDate | 2018-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.