| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F2438-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F2-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-243
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-243
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F2-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F212-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F230-04 |
| filingDate |
2020-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111249303-B |
| titleOfInvention |
Nitric oxide and cisplatin co-delivery poly-prodrug nanoparticles and preparation and application thereof |
| abstract |
The invention belongs to the field of medical polymers, and discloses a nitric oxide and cisplatin co-delivery poly-prodrug nanoparticle and preparation and application thereof. The invention utilizes P-chloromethyl styrene, cisplatin and other raw materials to prepare prodrug monomers for releasing nitric oxide and cisplatin, and utilizes a one-step method to polymerize with high conversion rate to obtain a polymer P (DMA-co-Pt-co-NO) containing two prodrug repeating units. In the reductive environment of tumor cells, the nitro group responds to GSH to release NO; the tetravalent platinum responds to the GSH to release cisplatin, the high-concentration GSH in a tumor microenvironment is fully utilized to realize drug release, and the promotion effect of NO on the drugs is exerted. The prodrug nanoparticles improve the water solubility and stability of the drug and have controllable release characteristics. |
| priorityDate |
2020-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |