| abstract |
A network of reusable, spatially multiplexed microfluidic channels, each channel including an inlet, an outlet, and a reaction vessel in between. The individual channels may operatively share a main output channel or common output channel, which defines the network output and optionally leads to a waste storage volume. Alternatively, multiple channels are created to individually lead to the storage volume. The individual reaction vessels are sized to substantially prevent the formation of air bubbles as the fluid sample flows through the reaction vessel, thus being completely filled and completely emptied. The entire channel network is configured to spatially lock the fluid sample by pressing the fluid sample against the closed valve with the second fluid to substantially immobilize the fluid sample, thereby preventing drift due to changes in environmental conditions during measurement. Thereafter, the fluid sample is flushed through the now open valve with a second continuously applied fluid pressure. Systems and methods for photometric measurements of multiple fluid samples using such channel networks. |