http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111239285-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-047 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-8679 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111239285-B |
| titleOfInvention | A kind of content detection method of genotoxic impurities in tenofovir alafenamide |
| abstract | The invention discloses a method for detecting the content of genotoxic impurities in tenofovir alafenamide. The detection method of the present invention comprises the following steps: preparing tenofovir alafenamide to be tested into a test solution, preparing impurity E and impurity G into reference substance solutions with different concentrations; Phase chromatographic detection, respectively take the chromatographic peak area of impurities E and G as the ordinate, respectively take the concentration of impurities E and G in the reference solution as the abscissa to make a standard curve; The test solution is subjected to the described high performance liquid chromatography detection, Obtain the peak areas of impurities E and G in the solution of the test product, and according to the standard curve, obtain the contents of impurities E and G in tenofovir alafenamide. By using the method of the invention, the sensitivity of the detection method can be greatly improved, the equipment and instruments are all common, the detection cost is low, the operation is extremely simple, and the detection cost and detection time are greatly saved. |
| priorityDate | 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.