http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111235128-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01244 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01087 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01069 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-00 |
filingDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-111235128-B |
titleOfInvention | A kind of synthetic method of GalNAcα1,3Gal or Galα1,3Gal glycosidic bond oligosaccharide |
abstract | The invention discloses a synthesis method of GalNAcα1,3Gal or Galα1,3Gal glycosidic bond oligosaccharide. The method of the present invention comprises: performing α1,2-fucosylation modification on the non-reducing end Gal of the target oligosaccharide, so that the substrate can be converted by α1,3-N-acetylgalactosaminyltransferase or α1,3- Galactosyltransferase recognizes and synthesizes GalNAc(Fucα1,2)α1,3Gal or Gal(Fucα1,2)α1,3Gal glycosidic bonds, and then removes fucose to synthesize GalNAcα1,3Gal or Galα1,3Gal glycosidic bonds. target oligosaccharide. The invention combines the high regioselectivity and high efficiency of enzymatic synthesis, and realizes the synthesis of target molecules with higher yield. In addition, the glycosyltransferase, glyconucleoside generating enzyme and glycokinase used in the present invention are all prokaryotic sources, have the advantages of high protein expression, wide substrate adaptability and high catalytic efficiency, and can be used for mass preparation. |
priorityDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 495.