http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111234016-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 |
| filingDate | 2020-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111234016-B |
| titleOfInvention | Fully human monoclonal antibody of anti-complement C5 molecule and application |
| abstract | The invention discloses a fully human monoclonal antibody of an anti-complement C5 molecule, wherein a light chain and a heavy chain of the antibody have unique CDR regions, so that the antibody has excellent antigen binding activity, and the antibody has obvious effect of inhibiting the lysis of CHO cells and erythrocytes sensitized by the antibody in a cell lysis inhibition experiment. The anti-C5 monoclonal antibody disclosed by the invention can obviously improve the survival rate of mice in the treatment of MRL/lpr lupus erythematosus mice, and obviously improve the symptoms of proteinuria, glomerular score, interstitial inflammation, vasculitis, crescent body/necrosis and the like of a treatment group, thereby showing that the monoclonal antibody provided by the invention has excellent application prospect in the preparation of autoimmune disease treatment medicines. |
| priorityDate | 2020-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 667.