http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111233762-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111233762-B |
| titleOfInvention | Levatinib and p-hydroxybenzoic acid eutectic crystal and preparation method thereof |
| abstract | The invention discloses a Levatinib and p-hydroxybenzoic acid eutectic crystal and a preparation method thereof. The co-crystal comprises lenvatinib and p-hydroxybenzoic acid in a molar ratio of 1: 1; the X-ray powder diffraction pattern of the eutectic measured by Cu Kalpha rays has characteristic peaks at diffraction angles 2 theta of 6.3 +/-0.2 degrees, 10.6 +/-0.2 degrees, 12.4 +/-0.2 degrees, 14.6 +/-0.2 degrees, 17.5 +/-0.2 degrees and 18.4 +/-0.2 degrees. The invention converts the lenvatinib into a brand new eutectic of the lenvatinib and the p-hydroxybenzoic acid for the first time, and the lenvatinib and the p-hydroxybenzoic acid eutectic have higher dissolution rate and larger apparent solubility. The preparation method of the eutectic of lenvatinib and p-hydroxybenzoic acid has the advantages of simple process, easy control of crystallization process, good reproducibility, suitability for industrial production and wide application prospect. |
| priorityDate | 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.