http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111228217-B

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filingDate 2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111228217-B
titleOfInvention Submicron emulsion containing clopidogrel or phospholipid complex of clopidogrel salt and preparation method thereof
abstract The invention belongs to the field of medicines, and discloses a submicron emulsion containing a phospholipid complex of clopidogrel or clopidogrel salt, which comprises the following components: phospholipid complex, vegetable oil, emulsifier, solubilizer, stabilizer, pH regulator and water; the phospholipid complex is prepared by the following method: dissolving clopidogrel and/or clopidogrel salt and phospholipid in an organic solvent, reacting, and removing the organic solvent to obtain the phospholipid complex. The invention utilizes clopidogrel and/or clopidogrel salt and phospholipid to form phospholipid complex, then prepares submicron emulsion, can be directly injected to patients, and after entering blood, the concentration of clopidogrel and/or clopidogrel salt rises rapidly, thus being capable of treating patients rapidly; the clopidogrel and/or clopidogrel salt and phospholipid are utilized to form a phospholipid complex, so that the stability of the clopidogrel and/or clopidogrel salt is improved, and the overall stability of the submicron emulsion is also improved.
priorityDate 2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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