http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111227799-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2503-40 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61D7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0042 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61D7-00 |
| filingDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111227799-B |
| titleOfInvention | Method for manufacturing high-sensitivity biological probe for in-vivo detection of brain tissue methylmercury |
| abstract | The invention relates to a method for manufacturing a high-sensitivity biological probe for in-vivo detection of brain tissue methylmercury, which comprises the following steps of a) separating and purifying hexameric ferritin, and preparing a hexameric ferritin solution by dialysis and desalination; b) preparing a chloroauric acid solution; c) preparing a sodium hydroxide solution and a hydrochloric acid solution; d) uniformly mixing the solution of the hexameric ferritin prepared in the step a and the solution of the chloroauric acid prepared in the step b, and adjusting the pH value of the mixed solution by using the solution of the sodium hydroxide prepared in the step c; e) and standing for reaction to obtain the methyl mercury detection biological probe. The characteristic that the gold nanocluster can be used for biological imaging and the characteristic that the hexamer ferritin can cross a blood brain barrier are utilized, so that the gold nanocluster can enter brain tissues for biomedical imaging, and the gold nanocluster has high stability and specificity and does not need to use dyes; the hexadecamer ferritin-gold nanocluster can be applied to mercury detection of brain tissues in organisms with methyl mercury poisoning. |
| priorityDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.