http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111214708-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-414 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-32 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 |
| filingDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111214708-B |
| titleOfInvention | Composite film carrying biological active factor PLA/PLGA/CS and preparation method thereof |
| abstract | The invention discloses a composite film carrying a bioactive factor PLA/PLGA/CS and a preparation method thereof. The invention utilizes the mode of combining electrostatic spinning and electrostatic spraying, takes the PLA film as a sealing layer, utilizes the compactness of the PLA film to prevent the diffusion of the medicine and provides mechanical support; the PLGA microspheres are used as sandwich layers and load medicines; the PLA/PLGA/CS composite membrane with a membrane/sphere/membrane three-layer structure is prepared by using the larger porosity and higher biocompatibility of the CS membrane as a regulation and control slow release layer, directly contacting with a damaged area, and simultaneously planting seed cells to achieve the purpose of nerve repair. The composite film has a stable structure and certain mechanical strength, the tensile strength is 2.83 +/-0.31 MPa, and the elongation at break is 53.25 +/-0.18%; the medicine can be well loaded, the medicine slow release effect is good, the medicine can be released for more than two months, and the time required by spinal cord injury repair is met; meanwhile, the compound has no cytotoxicity, successfully induces the PC-12 cells to be divided into neurons in 5 days, and is beneficial to nerve repair. |
| priorityDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.