| abstract |
A TNT/IL-4/G nano-biological material and preparation method, comprising a pure titanium base material, a plurality of titanium dioxide nanotubes arranged on the pure titanium base material in an array, the interior of the titanium dioxide nanotubes is filled with IL-4, and the A mixed layer is filled between the adjacent outer surfaces of the titanium dioxide nanotubes, and the mixed layer is composed of a combination of hydrogel and heparin. In the present invention, the TNT/IL-4/G nano-biological material can further promote the polarization of macrophage M2, increase the expression of macrophage M2-related genes, reduce the release of inflammatory factors, achieve the purpose of anti-inflammatory, and make macrophage M2 The vascular endothelial growth factor released by the cells increases, thereby accelerating endothelialization and reducing thrombosis. At the same time, the released heparin directly acts on platelets, which also shows high anticoagulation efficiency and achieves the purpose of reducing thrombosis. |