| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 |
| filingDate |
2020-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80c5d706d032286053d7c82e39e4681c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df7f16102b57f965a291c281de99c4ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0197e665695b1d15973af91a817364f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2301459c7d962d4aac8ccf7d5701b6a2 |
| publicationDate |
2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111205324-A |
| titleOfInvention |
Synthesis and application of a two-photon ratiometric probe for locating mitochondria and detecting hydroxyl radicals |
| abstract |
The invention relates to a synthesis method and application of a two-photon ratio probe for locating mitochondria and detecting hydroxyl radicals, comprising: reacting bromopropylamine and triphenylphosphine to form compound I; combining compound I with 4-bromo-1, 8-naphthalene anhydride is reacted to form compound II; compound II is reacted with hydrazine hydrate to form compound III; compound III is reacted with ethyl acetoacetate to obtain a two-photon ratio probe for locating mitochondria and detecting hydroxyl radicals. The invention has the advantages of simple preparation, sensitive detection, good selectivity and the like. It is worth noting that, using this invention, the present invention successfully realized the imaging analysis of changes in mitochondrial ·OH in the brains of depressive mice at the in vivo level. |
| priorityDate |
2020-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |