http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111205308-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-182 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-22 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-645 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-548 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111205308-B |
| titleOfInvention | Sulfo-diketone piperazine compound and preparation method and application thereof |
| abstract | The invention relates to a microbial medicine technology, in particular to a preparation method and application of a thiodiketopiperazine compound, wherein the thiodiketopiperazine compound is derived from a fermentation product of epicoccum nigrum. The molecular formula of the compound is C 19 H 22 N 2 O 7 S 2 The structure is shown in formula I; the compound obtained by the invention has the same positive control sorafenib (IC) 50 Value of 8.2. mu.M) comparable activity against Huh7.5 hepatoma cells, IC 50 The value is 9.5 mu M, and the compound can be fermented and produced by microorganisms, and is expected to be further developed into an anti-liver cancer medicament or a lead compound thereof. |
| priorityDate | 2020-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.