http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111205294-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2020-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111205294-B |
| titleOfInvention | Preparation method of Reidesciclovir intermediate |
| abstract | The invention relates to the technical field of medical intermediates, in particular to a preparation method of a ridciclovir intermediate, the chemical name of the preparation method is (2R,3R,4R,5R) -2- (4-aminopyrrole [2,1-f ] [1,2,4] triazine-7-yl) -3, 4-bis (benzyloxy) -5- ((benzyloxy) methyl) tetrahydrofuran-2-nitrile, and the preparation method comprises the following steps: 1) asymmetrically adding 2,3, 5-tribenzyloxy-D-ribono-1, 4-lactone in a solvent to form (2R,3R,4R,5R) -3, 4-bis (benzyloxy) -5- ((benzyloxy) methyl) -2-hydroxytetrahydrofuran-2-carbonitrile; 2) (2R,3R,4R,5R) -3, 4-bis (benzyloxy) -5- ((benzyloxy) methyl) -2-hydroxytetrahydrofuran-2-carbonitrile is reacted with a hydroxy activator and then with 7-iodopyrrolo [2,1-f ] [1,2,4] triazin-4-amine in a solvent to form (2R,3R,4R,5R) -2- (4-aminopyrrole [2,1-f ] [1,2,4] triazin-7-yl) -3, 4-bis (benzyloxy) -5- ((benzyloxy) methyl) tetrahydrofuran-2-carbonitrile. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11780844-B2 |
| priorityDate | 2020-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.