http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111205288-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2020-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111205288-B |
| titleOfInvention | Synthesis method of (1S,12bS) lactam ester compound |
| abstract | The present invention provides a process for the synthesis of a (1S,12bS) lactam ester compound by di-esterifying a dihydrocarboline of formula (II) in the presence of an iridium metal procatalyst, a chiral bisphosphine ligand, and one or more than one halogen-containing additive, as shown in the reaction scheme belowThe compound is subjected to asymmetric hydrogenation and lactamization in an organic solvent under hydrogen atmosphere to obtain the (1S,12bS) lactam ester compound shown in the formula (I), wherein R is 1 、R 2 、R 3 As defined in the specification. The method has the advantages of mild reaction conditions, excellent enantioselectivity and diastereoselectivity, high chemical yield and high industrial application value. |
| priorityDate | 2020-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.