http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111197020-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-181 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-76 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-465 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-76 |
| filingDate | 2020-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111197020-B |
| titleOfInvention | Recombinant bacterium for producing milbemycins as well as construction method and application thereof |
| abstract | The invention discloses a recombinant bacterium for producing milbemycins and a construction method and application thereof, belonging to the technical field of molecular biology. In order to improve the extraction purity and the titer of the milbemycins A3/A4, the invention provides a recombinant bacterium for producing the milbemycins, wherein the starting strain of the recombinant bacterium is Streptomyces bingchenensis X-7 (the preservation number of the strain is CGMCC 1734), and the recombinant bacterium is obtained by knocking out the cyp41 gene in the starting strain to inactivate the gene, when the recombinant bacterium prepared by the invention is used for producing the milbemycins A3/A4, the alpha 9/alpha 10 component of the milbemycins is reduced or inactivated, so that the purification process of the milbemycins A3/A4 is simplified, the titer of the milbemycins A3+ A4 is improved, and the production cost of the milbemycins is reduced. |
| priorityDate | 2020-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 261.