| abstract |
The invention belongs to the field of medicinal chemistry, and relates to a class of compounds as TGF-βR1 inhibitors and applications thereof. Specifically, the present invention provides compounds shown in formula I or isomers thereof, pharmaceutically acceptable salts, solvates, Crystals or prodrugs, methods for their preparation and pharmaceutical compositions containing these compounds and these compounds or compositions for use in the treatment and/or prevention of TGF-βR1 related diseases such as cancer, histoproliferative diseases, fibrosis and inflammatory diseases and other diseases. The compounds of the present invention show significant inhibitory activity on TGF-βR1 kinase, and are very promising as therapeutic agents for TGF-βR1-related diseases. |