http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111187270-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 |
| filingDate | 2020-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111187270-B |
| titleOfInvention | Chiral pyrazolone spiro [ cyclopentene ] spirooxindole compound and preparation method and application thereof |
| abstract | The invention discloses chiral pyrazolone spiro [ cyclopentene ]]The invention relates to a spiro oxindole compound, a preparation method and application thereof, wherein the preparation method of the compound comprises the following steps: mixing pyrazolone dienoxindole derivative (II) and gamma-substituted dienoic acid ester (III) with a solvent, adding chiral phosphine catalyst and alkali, stirring and reacting for 0.5-24 hours at-50 ℃ to obtain chiral pyrazolone spiro [ cyclopentene ]]Spirooxindoles (I). The method has the characteristics of easily obtained raw materials, simple and convenient operation, high chemical selectivity, high regioselectivity and the like, and the synthesized compound has certain antitumor activity, so the method has great implementation value and application prospect. |
| priorityDate | 2020-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.