| abstract |
The invention belongs to the technical field of medicines, and relates to an ATX inhibitor based on an indole parent nucleus, an optical isomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, a preparation method of the ATX inhibitor and the optical isomer, the pharmaceutically acceptable salt, the solvate or the prodrug, and a pharmaceutical composition containing the ATX inhibitor. The indole derivative and the optical isomer, the pharmaceutically acceptable salt, the solvate or the prodrug thereof are shown as a general formula I. Wherein, L, X, R 1 ‑R 8 As described in the claims and specification. The compound of the invention has strong ATX inhibitory activity in vitro, so the compound can be used for preparing medicines for treating and/or preventing cancers and fibrotic diseases. |