http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111187154-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C63-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-68 |
| filingDate | 2019-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111187154-B |
| titleOfInvention | Synthetic method of sitagliptin intermediate 2,4, 5-trifluoro phenylacetic acid |
| abstract | The invention provides a synthetic method of a sitagliptin intermediate 2,4, 5-trifluoro phenylacetic acid, which comprises the steps of substitution reaction, hydrolysis reaction and decarboxylation reaction, wherein A, a compound of a formula 5 is prepared by the substitution reaction of a compound 4, or the substitution reaction and the hydrolysis reaction of the compound; B. carrying out hydrolysis reaction on the compound shown in the formula 5 to prepare a compound shown in a formula 6; C. the 2,4, 5-trifluoro-phenylacetic acid is prepared by decarboxylation reaction of a compound shown in a formula 6 under the catalysis of a catalyst, wherein the catalyst is a metal oxide. The synthesis process has low cost, high yield and strong applicability in industrial scale-up production, and can be used for preparing the 2,4, 5-trifluoro-phenylacetic acid compound. |
| priorityDate | 2018-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.