http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111172164-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6ed83b9d5c28c6c356d1d08d58501e7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate | 2020-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7846ab3c09de94dcc2ae5dc4e24ed5b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8f526be61bdde12778df813939573e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16db8b9c9a5fb23befcd84e61f65780d |
| publicationDate | 2020-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111172164-A |
| titleOfInvention | A composition and method for arbitrary nucleic acid editing |
| abstract | The present invention discloses a composition and method for any nucleic acid editing. A composition for carrying out targeted cleavage of any nucleic acid, comprising two main components: component A: oligonucleotide probe: the oligonucleotide probe is composed of two parts, one part is complementary to the target substrate, and the other part is complementary to the target substrate. A part has nucleic acid secondary structure; Component B: Endonuclease molecule: The endonuclease molecule can recognize the nucleic acid secondary structure of the oligonucleotide probe to bind to the probe, and can also cut DNA or RNA substrates. In the present invention, the secondary hairpin structure (stem-loop structure) on the oligonucleotide probe can be directly recognized by the endonuclease molecule to form a complex molecule. The probability that the complex molecule collides with the target substrate will be greater than the probability that two independently diffused molecules of the probe and the enzyme collide with the target substrate at the same time, thereby improving the efficiency of gene editing. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113975398-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113975398-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107686842-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113637670-A |
| priorityDate | 2020-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 601.