http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111171595-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 |
| filingDate | 2020-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111171595-B |
| titleOfInvention | A class of azafluoroborondipyrrole near-infrared fluorescent dyes and preparation method thereof |
| abstract | The invention relates to a class of azafluoroborodipyrrole near-infrared fluorescent dyes and a preparation method. The dye is composed of a hydrophilic chain, an alkyl chain, an electron donating group and an azapyrrolidine skeleton. The target dye is obtained through the following steps: (1) the aromatic aldehyde and aromatic ketone are reacted under alkaline conditions to obtain chalcone; (2) the obtained chalcone is reacted with nitromethane under alkaline conditions; (3) Ring-closure reaction, with the intermediate product obtained in (2) and a large amount of ammonium acetate reaction; (4) coordination reaction, with the intermediate product obtained in (3) and-BF 2. Coordination reaction occurs; (5) addition reaction; That is, the intermediate product obtained in (4) undergoes a click addition reaction with the prepared oxygen chain to obtain the target dye. The target dye not only has good water solubility and good photothermal effect, but also can be used for multimodal imaging with single wavelength excitation, including photoacoustic imaging/fluorescence imaging, photothermal imaging, etc. guided photodynamic and photothermal synergistic tumor therapy. |
| priorityDate | 2020-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.