http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111171075-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6518 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6518 |
| filingDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111171075-B |
| titleOfInvention | A kind of preparation method of forsefluconazole |
| abstract | The invention provides a preparation method of forsifluconazole, comprising the following steps: preparing fluconazole dichlorophosphate: under nitrogen protection, at a temperature of ‑10 to 0 DEG C, adding a solution of triethylamine in dichloromethane Phosphorus oxychloride was slowly added dropwise, after the dropping was completed, the temperature was maintained at -10 to 0 °C and stirred for 1 hour, the dichloromethane solution of fluconazole was slowly added dropwise, and the reaction was monitored by TLC; the temperature was maintained at -10 to 0 °C, and water was added. Stir for 30 minutes, add an inorganic base until the pH of the aqueous phase is at least 8, stand for stratification, separate the upper aqueous phase, the organic phase contains fluconazole dichlorophosphate, pass through fluconazole-fluconazole dichlorophosphate ‑Fluconazole dibenzyl phosphate ‑ Forse fluconazole ammonium salt ‑ Forse fluconazole process to prepare forse fluconazole, improve yield, controllable preparation of intermediates, raw materials can be recycled and reused, reduce raw material waste and Organic waste pollution. |
| priorityDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.