| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1592ac46e682c86bd6d78a1759aa725 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-4266
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-4283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-824
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2409
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J35-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J27-122 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate |
2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c97351f59f9ac850322a22f481e00f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc581097568c206f15d070dd9dbec0b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4932ae90b9cb0032010f3cfda9c0adf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42e1f567b69173f949da8d2905105d17 |
| publicationDate |
2020-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111171002-A |
| titleOfInvention |
A kind of preparation method of PARP inhibitor intermediate |
| abstract |
The present invention relates to a kind of PARP inhibitor, especially the intermediate (R)-2-(1-(2-(tert-butyloxy)-2-oxoethyl)-2-methylpyrrolidine- of Pamiparib 2 base)-6-fluorine-1-toluenesulfonyl-1H-indole-4-The preparation method of methyl carboxylate, described method in the case of using palladium (Pd) catalyst and cuprous iodide (Cul) The palladium catalyst contains at least one or both of Pd(dppf)Cl2 and Pd(dtbpf)Cl2. The method can improve the conversion rate of raw materials and obtain products with high chiral purity. The method has stable production, good repeatability and high yield, and saves production costs in industrial large-scale production. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115138396-A |
| priorityDate |
2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |