| abstract |
The invention discloses a series of propargylamine derivatives and a synthesis method thereof. The synthetic method of the derivative mainly includes: 1) taking any one of the structures shown in the following formulas (A) to (E) and placing excess dibromoalkane in an organic solvent, adding an acid binding agent to react to obtain an intermediate 2) get intermediate and N-methyl propargyl amine and place in organic solvent, add acid binding agent to carry out substitution reaction, obtain corresponding target compound crude product. The method of the invention is simple and easy to operate, and has high yield; the obtained target compound can selectively inhibit MAO-B. The structures shown in the formulas (A) to (E) are: Wherein R 1 is H, F, Cl, Br, OH, OCH 3 , NO 2 , CH 3 , CF 3 , COCH 3 , COOCH 3 , CH 2 OH substituted at any position, or C 2 -C 5 is directly connected or branched Paraffin; X is O, N, S or C. |