http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111154785-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2020-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111154785-B |
| titleOfInvention | Method for modifying ubiquitin and inhibiting ubiquitination pathway |
| abstract | The invention discloses a method for modifying ubiquitin and inhibiting ubiquitination pathway. This modification is achieved by a family of effector proteins secreted by the type III secretion system in gram-negative bacteria. The effector protein of the family is Adenosine Diphosphate (ADP) ribosyltransferase, specifically performs single ADP ribosylation modification on threonine residue at the 66 th position of ubiquitin molecule in eukaryote, and has no modification effect on ubiquitin-like protein SUMO and NEDD 8. The modification effect on ubiquitin can not be reversibly modified by hydrolase for removing ADP ribosylation modification in eukaryotic cells, so that ubiquitin-mediated signal pathways in host cells are effectively damaged, and the method plays an important role in killing tumor cells, changing cell signal pathways and the like. |
| priorityDate | 2020-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.