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filingDate 2020-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e78653bd7d639c89e181c0ac5a4bf2a0
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publicationDate 2020-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111154118-A
titleOfInvention A kind of single crystal polymer micelle with different aspect ratio and preparation method thereof
abstract The invention belongs to the technical field of polymer materials, in particular to a single crystal polymer micelle with different aspect ratios and a preparation method thereof, comprising the following steps: (1) synthesis of block polymers, (2) PCL-containing crystallization Synthesis of block ionic amphiphilic block copolymer, (3) Preparation of single crystal polymer micelle: The ionic amphiphilic block copolymer is dissolved in a good solvent and added dropwise at a preset speed Ultrapure water was used to obtain the initial micelle solution; then, the Hofmeister ion sequence solution was added dropwise, and after stirring, single crystal polymer micelles with different aspect ratios were obtained. The preparation method of the invention has the advantages of simple operation, simple process and mild preparation conditions, and can prepare two-dimensional single crystal structure polymer micelles with a size of micrometer in a relatively short time; Large loading capacity; longer in vivo circulation time than zero-dimensional spherical structures when used for in vivo drug delivery.
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Total number of triples: 44.