http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111153868-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-42 |
| filingDate | 2020-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111153868-B |
| titleOfInvention | Synthesis method of 4- (4-chlorphenyl) -2-trifluoromethyl-3-oxazole-5-ketone |
| abstract | The invention discloses a method for synthesizing 4- (4-chlorphenyl) -2-trifluoromethyl-3-oxazole-5-ketone, which comprises the following steps: dispersing alpha-p-chlorophenyl glycine in a solvent in a reaction kettle, sequentially dropwise adding trifluoroacetic acid, triethylamine and a solid phosgene solution into the solvent, stirring for reaction, adding water into the reaction kettle, standing for layering when the amount of the alpha-p-chlorophenyl glycine in a liquid phase is controlled to be less than 0.5%, adding the solvent into a water phase for extraction, combining solvent layers, and distilling the combined solvent layers under reduced pressure to remove the solvent to obtain a product; the solid phosgene solution is obtained by dissolving solid phosgene in an organic solvent; the synthesis method has less side reaction, and the obtained product has higher purity and yield, wherein the product purity is more than 95 percent, and the yield is more than 94 percent; the synthetic method of the invention does not adopt phosphorus trichloride, has low requirements on environment, does not generate phosphorus-containing wastewater, generates less wastewater in the whole reaction, and is safe and environment-friendly. |
| priorityDate | 2020-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.