| abstract |
The invention discloses a method for synthesizing [ 18 F]-GE-179, the steps are as follows: Step 1, a cyclotron generates H protons to bombard 18O - heavy oxygen water, and utilizes a nuclear reaction 18O(p,n)18F to generate 18F ions; After the 18 F ion is enriched by the QMA column and eluted into the reaction flask by the eluent, [K/K 2.2.2 ] +18 F － is obtained; precursor 2 and [K/K 2.2.2 ] +18 F - reacts to generate intermediate 3; step 2, dissolves precursor 1, and adds an alkaline reducing agent to obtain reduced intermediate 4; step 3, directly adds intermediate 3 to the reaction solution of step 2 to obtain 18 F-GE179. The method for synthesizing [ 18 F]-GE-179 provided by the present invention adopts a thiol dimer as a labeling precursor, performs a nucleophilic substitution reaction immediately after reduction to obtain 18 F-GE179, has a high labeling yield, and can be used in the preparation of clinical senile Dementia, schizophrenia PET imaging agents play an important role. |