http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111148758-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-572 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2018-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111148758-B |
| titleOfInvention | Bispecific antigen binding molecules that bind Staphylococcus target antigens and complement components and uses thereof |
| abstract | According to certain embodiments, the present disclosure provides a bispecific antigen binding molecule comprising a first antigen binding domain that specifically binds a Staphylococcus sp. target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen binding molecules of the disclosure are capable of binding a Staphylococcus sp. target antigen with an EC of about 10 nM or less, and/or are capable of promoting complement deposition in Staphylococcus sp. with an EC of about 10 nM. genus species. Antibodies of the disclosure are useful in the treatment of diseases in which inhibition or reduction of the growth of Staphylococcus species is desirable and/or therapeutically beneficial, e.g., in the treatment of staphylococcal infections, including skin infections, cellulitis, pneumonia , meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for the prophylaxis or treatment of staphylococcal infections occurring as a result of surgical procedures. |
| priorityDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 400.