http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111138375-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a32f59081d7165f2fc26eb1f3fbb31ee |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-20 |
| filingDate | 2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cef24fb774d6cb7803fc02a93c841462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ed53fbb6e41f61407ca271a80e095f1 |
| publicationDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111138375-A |
| titleOfInvention | A kind of chiral purification method of pharmaceutical intermediate |
| abstract | The invention provides a chiral purification method of a pharmaceutical intermediate. The method for chiral purification of the pharmaceutical intermediate includes the following steps: (1) adding the compound represented by the formula A 4 with low optical purity into the solvent A, mixing and stirring, and filtering to obtain a filtrate; (2) adding the compound represented by the step (1) After the obtained filtrate is concentrated for one time, solvent B is added to dissolve, and then concentrated for a second time. Finally, solvent B is added to mix and stir, and filtered to obtain the compound represented by formula A 4 with high optical purity ; The structural formula is shown below. The chiral purification method for pharmaceutical intermediates of the present invention can perform chiral purification by using cheap solvents, with mild conditions and simple operation, and can make the optical purity of A 4 reach 99.90-99.99%, and the yield is high, up to more than 90 percent. |
| priorityDate | 2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.