| abstract |
The invention discloses a 2-ethyl-4,6-disubstituted pyridine compound and a synthesis method thereof. The structural formula of the compound is: Wherein: R 1 and R 2 are respectively phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 3-chlorophenyl, 4-methoxyphenyl, 4-fluoro Phenyl, furan or pyridine. The invention uses alkenyl imine and ketone as raw materials, and without the participation of metals, through cycloaddition reaction, a series of multi-substituted pyridine compounds are efficiently constructed. Good functional group compatibility and moderate to excellent yields. The 2-ethyl-4,6-disubstituted pyridine compounds synthesized by applying the method have good application prospects in the fields of scientific research and industrial production. |