http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111135298-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-644 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111135298-B |
| titleOfInvention | A kind of amphiphilic fluoroboron dipyrrole compound and its preparation method and use |
| abstract | The present invention relates to an amphiphilic fluoroboron dipyrrole compound, a preparation method and application thereof, and the compound is synthesized from polyethylene glycol, a polypeptide and a fluoroboron dipyrrole photosensitizer through covalent bond connection. The compounds of the present invention can self-assemble in an aqueous solution to form nanoparticles with a core-shell structure, that is, the outer layer is a polypeptide chemically bonded to polyethylene glycol, and the inner core is an aggregate of fluoroboron dipyrrole photosensitizers. The nanoparticles have high stability and good biocompatibility in aqueous solution. Nanoparticles can remove the outer layer of polyethylene glycol in tumor tissue to reduce the particle size, and at the same time, the surface-exposed polypeptides specifically bind to the highly expressed receptors on the surface of cancer cells to achieve the purpose of targeted delivery of photosensitizers. In addition, nanoparticles can be excreted through urine and feces, thereby greatly reducing their phototoxic side effects on normal tissues and skin, and can be used as delivery of various photosensitizer drugs in tumor photodynamic therapy. |
| priorityDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.