http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111116771-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0063 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0003 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 |
| filingDate | 2019-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111116771-B |
| titleOfInvention | Polysaccharide extracted from Undaria pinnatifida and application thereof in preparation of alpha-glucosidase activity inhibition drugs |
| abstract | The invention discloses an undaria pinnatifida polysaccharide and application thereof in preparing a medicament for inhibiting activity of alpha-glucosidase. The two polysaccharides Up-3 and Up-4 prepared by the invention have the characteristic molecular weights of 78-282 kDa and 41-314 kDa respectively; up-3 mainly comprises glucuronic acid, mannose and fucose, and Up-4 mainly comprises rhamnose, glucuronic acid and fucose; inhibitory Activity against alpha-glucosidase IC 50 The values are 113.40 +/-3.02 mu g/mL and 50.53 +/-3.47 mu g/mL respectively, and the oral maltose-containing oral liquid has the effect of remarkably inhibiting the blood sugar rise caused by oral maltose. This shows that the sulfated polysaccharides Up-3 and Up-4 achieve the hypoglycemic effect by inhibiting the activity of alpha-glucosidase in intestinal tract, thereby reducing the postprandial blood glucose level. |
| priorityDate | 2019-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.